Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …

Cancer in the broader sense refers to more than 277 different types of cancer disease.
Scientists have identified different stage of cancers, indicating that several gene mutations …

Cadmium (Cd) is a known nephrotoxic heavy metal and proximal tubules are the major
target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal …

Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is
believed to ensure a condensed and transcriptionally inert chromatin conformation …

Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Histone acetylation in single-cell eukaryotes relies on acetyl coenzyme A (acetyl-CoA)
synthetase enzymes that use acetate to produce acetyl-CoA. Metazoans, however, use …