The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Autism is an etiologically and clinically heterogeneous group of disorders, diagnosed solely
by the complex behavioral phenotype. On the basis of the high-heritability index, geneticists …

Background Tuberous sclerosis complex is a multisystem genetic disorder with a range of
physical manifestations that require evaluation, surveillance, and management. Individuals …

Tuberous sclerosis is a genetic multisystem disorder characterised by widespread
hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung, and liver …

Background Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic
disorder. Many gaps remain in the understanding of TSC because of the complexity in …

Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a"
female protective effect"(FPE) envisions males and females have" differing thresholds" …

Background An emerging literature on behavioural phenotypes has highlighted apparent
associations between autism spectrum disorders (ASDs) or ASDrelated phenomenology …

Background Most evidence for TSC-associated neuropsychiatric disorders (TAND) to date
have come from small studies and case reports, and very little is known about TAND in …

Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder.
Genetic disorders frequently accompany autism spectrum disorder, such as tuberous …

Objective: The purpose of this study was to assess the prevalence of and to identify
epidemiologic, genetic, electrophysiologic, and neuroanatomic risk factors for autism …