Background: Chemoresistance to 5-fluorouracil (5-FU) is a major barrier to influence the
treatment efficiency of colorectal cancer (CRC) patients, while the precise molecular …

Despite tremendous achievements in the field of targeted cancer therapy, chemotherapy is
still the main treatment option, which is challenged by acquired drug resistance. Various …

Cancer therapies, such as chemotherapy and radiotherapy, are often unsatisfactory due to
several limitations, including drug resistance, inability to cross biological barriers, and toxic …

Doxorubicin (Dox) is the standard treatment approach for osteosarcoma (OS), while
acquired drug resistance seriously attenuates its treatment efficiency. The present study …

Drug repurposing identifies new clinical indications for existing drugs. It can be used to
overcome common problems associated with cancers, such as heterogeneity and resistance …

Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial
mediators of intercellular communication within the complex tumour microenvironment …

Abstract Introduction Long noncoding RNAs (lncRNAs) play crucial roles in regulating
various hallmarks in cancers. Triple‐negative (Estrogen receptor, ER; Human epidermal …

Simple Summary Long-chain Acyl-CoA synthetase (ACSL) family members are involved in
long-chain fatty acid activation, a crucial step for cells to utilize fatty acids (FAs) in the …

Intra-tumoral heterogeneity is maintained by cancer stem cells (CSCs) with dysregulated self-
renewal and asymmetric cell division (ACD). According to the cancer stem cell theory, by …

Aims Orf virus (ORFV) is a parapoxvirus causing contagious ecthyma in sheep and goats.
With inhibitory role of ORFV reported by previous studies, ORFV can be a candidate of …