Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy

S Sifuentes-Franco, DE Padilla-Tejeda… - International journal …, 2018 - Wiley Online Library
Diabetic nephropathy (DN) is the second most frequent and prevalent complication of
diabetes mellitus (DM). The increase in the production of oxidative stress (OS) is induced by …

Diabetes‐induced reactive oxygen species: mechanism of their generation and role in renal injury

S Fakhruddin, W Alanazi… - Journal of diabetes …, 2017 - Wiley Online Library
Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Oxidative stress in diabetic nephropathy with early chronic kidney disease

AG Miranda-Díaz, L Pazarín-Villaseñor… - Journal of diabetes …, 2016 - Wiley Online Library
The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage
produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of …

[HTML][HTML] Pericytes, an overlooked player in vascular pathobiology

D Ferland-McCollough, S Slater, J Richard… - Pharmacology & …, 2017 - Elsevier
Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …

A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

JC Jha, F Ho, C Dan, K Jandeleit-Dahm - Clinical Science, 2018 - portlandpress.com
Chronic renal and vascular oxidative stress in association with an enhanced inflammatory
burden are determinant processes in the development and progression of diabetic …

[HTML][HTML] Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects

X Li, Y Zhang, X Xing, M Li, Y Liu, A Xu… - Biomedicine & …, 2023 - Elsevier
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant
challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it …

Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: assessment of NF-κB and Nrf2 signaling system

K Manna, S Mishra, M Saha, S Mahapatra… - International journal …, 2019 - Taylor & Francis
Background Diabetic nephropathy (DN), an end-stage renal disorder, has posed a menace
to humankind globally, because of its complex nature and poorly understandable intricate …

[HTML][HTML] Kidney disease in diabetes mellitus: cross-linking between hyperglycemia, redox imbalance and inflammation

RG Amorim, GS Guedes, SML Vasconcelos… - Arquivos brasileiros de …, 2019 - SciELO Brasil
Chronic hyperglycemia is the key point of macro-and microvascular complications
associated with diabetes mellitus. Excess glucose is responsible for inducing redox …

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats

HO Abou-Hany, H Atef, E Said, HA Elkashef… - Chemico-biological …, 2018 - Elsevier
Diabetic Nephropathy (DN) is one of the main complications associated with diabetes
mellitus. Persistently elevated blood glucose level drives histopathological changes in renal …

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy

S Saxena, A Mathur, P Kakkar - Journal of cellular physiology, 2019 - Wiley Online Library
Mitochondrial dynamics play a critical role in deciding the fate of a cell under normal and
diseased condition. Recent surge of studies indicate their regulatory role in meeting energy …