Na+‐K+‐2Cl− Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia
Two genes encode the Na+‐K+‐2Cl− cotransporters, NKCC1 and NKCC2, that mediate the
tightly coupled movement of 1Na+, 1K+, and 2Cl− across the plasma membrane of cells …
tightly coupled movement of 1Na+, 1K+, and 2Cl− across the plasma membrane of cells …
Genomic determinants of hypertension with a focus on metabolomics and the gut microbiome
Epidemiologic and genomic studies have progressively improved our understanding of the
causation of hypertension and the complex relationship with diet and environment. The …
causation of hypertension and the complex relationship with diet and environment. The …
Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity
More than 800 million people in the world suffer from chronic kidney disease (CKD).
Genome-wide association studies (GWAS) have identified hundreds of loci where genetic …
Genome-wide association studies (GWAS) have identified hundreds of loci where genetic …
Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling
I Alesutan, TTD Luong, N Schelski… - Cardiovascular …, 2021 - academic.oup.com
Aims Uromodulin is produced exclusively in the kidney and secreted into both urine and
blood. Serum levels of uromodulin are correlated with kidney function and reduced in …
blood. Serum levels of uromodulin are correlated with kidney function and reduced in …
Autosomal dominant tubulointerstitial kidney disease: more than just HNF1β
Autosomal dominant tubulointerstitial kidney disease (ADTKD) refers to a group of disorders
with a bland urinary sediment, slowly progressive chronic kidney disease (CKD), and …
with a bland urinary sediment, slowly progressive chronic kidney disease (CKD), and …
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain
R Micanovic, KA LaFavers, KR Patidar… - American Journal …, 2022 - journals.physiology.org
Uromodulin [Tamm-Horsfall protein (THP)] is a glycoprotein uniquely produced in the
kidney. It is released by cells of the thick ascending limbs apically in the urine and …
kidney. It is released by cells of the thick ascending limbs apically in the urine and …
Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD)
L McCallum, K Brooksbank… - American Journal of …, 2021 - academic.oup.com
BACKGROUND Genome-wide association studies have identified single nucleotide
polymorphisms (SNPs) near the uromodulin gene (UMOD) affecting uromodulin excretion …
polymorphisms (SNPs) near the uromodulin gene (UMOD) affecting uromodulin excretion …
Nephrolithiasis secondary to inherited defects in the thick ascending loop of henle and connecting tubules
N Faller, NA Dhayat, DG Fuster - Urolithiasis, 2019 - Springer
Twin and genealogy studies suggest a strong genetic component of nephrolithiasis.
Likewise, urinary traits associated with renal stone formation were found to be highly …
Likewise, urinary traits associated with renal stone formation were found to be highly …