The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …

Computational trajectory inference enables the reconstruction of cell state dynamics from
single-cell RNA sequencing experiments. However, trajectory inference requires that the …

Iron is an essential element involved in a variety of physiological functions. In the pancreatic
beta-cells, being part of Fe-S cluster proteins, it is necessary for the correct insulin synthesis …

The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists
being prescribed in individuals with type 2 diabetes and obesity,. The impact of genetic …

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

Metal homeostasis is tightly regulated in cells and organisms, and its disturbance is
frequently observed in some diseases such as neurodegenerative diseases and metabolic …

A major hypothesis for the etiology of type 1 diabetes (T1D) postulates initiation by viral
infection, leading to double-stranded RNA (dsRNA)-mediated interferon response and …

Abstract Objective Islets of Langerhans contain heterogeneous populations of insulin-
producing β-cells. Surface markers and respective antibodies for isolation, tracking, and …

Protein citrullination plays a role in several autoimmune diseases. Its involvement in murine
and human type 1 diabetes has recently been recognized through the discovery of …

Blood glucose homeostasis requires proper function of pancreatic islets, which secrete
insulin, glucagon and somatostatin from the β-, α-and δ-cells respectively. Each islet cell …