La marrie extracellulaire (MEC) est un des principaux régulateurs du développement et de
l'homéostasie tissulaires. Des études à l'aide de systèmes de microenvironnements …

Many cancer investigations have focussed on the eradication of the cancer cell itself and in
doing so, overlook the inherent complexity and heterogeneity of solid tumors. Here, we …

In a recently developed human breast cancer model, treatment of tumor cells in a 3-
dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking …

3D cell cultures are rapidly becoming the method of choice for the physiologically relevant
modeling of many aspects of non-malignant and malignant cell behavior ex vivo …

Organs are made of the organized assembly of different cell types that contribute to the
architecture necessary for functional differentiation. In those with exocrine function, such as …

The architecture of a tissue is defined by the nature and the integrity of its cellular and
extracellular compartments, and is based on proper adhesive cell–cell and cell–extracellular …

Whether in sexual or asexual organisms, selection among cell lineages during development
is an effective way of eliminating deleterious mutations. Using a mathematical analysis, we …

The central problem in cancer biology is to understand why tumor cells continue to survive
and proliferate in situations where normal cells would arrest growth or apoptose. Although …

Altered glycosylation is commonly observed in colorectal cancer. In vitro models are
frequently used to study this cancer but little is known about the differences that may exist …

In melanoma, the relationship between sun exposure and the origin of mutations in either
the N-ras oncogene or the p53 tumour-suppressor gene is not as clear as in other types of …