Manganese-induced neurotoxicity: new insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation
DS Harischandra, S Ghaisas, G Zenitsky… - Frontiers in …, 2019 - frontiersin.org
Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …
“Manganism,” a neurological condition showing certain motor symptoms similar to …
Manganese and the brain
K Tuschl, PB Mills, PT Clayton - International review of neurobiology, 2013 - Elsevier
Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and
metabolism. Its homeostasis is tightly regulated; however, the mechanisms of Mn …
metabolism. Its homeostasis is tightly regulated; however, the mechanisms of Mn …
Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity
KS Kirkley, KA Popichak, MF Afzali, ME Legare… - Journal of …, 2017 - Springer
Background As the primary immune response cell in the central nervous system, microglia
constantly monitor the microenvironment and respond rapidly to stress, infection, and injury …
constantly monitor the microenvironment and respond rapidly to stress, infection, and injury …
Manganese and its role in Parkinson's disease: from transport to neuropathology
M Aschner, KM Erikson, EH Hernández… - Neuromolecular …, 2009 - Springer
The purpose of this review is to highlight recent advances in the neuropathology associated
with Mn exposures. We commence with a discussion on occupational manganism and …
with Mn exposures. We commence with a discussion on occupational manganism and …
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Chronic, sustained inflammation underlies many pathological conditions, including
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …
Toxicological and pathophysiological roles of reactive oxygen and nitrogen species
'Oxidative and Nitrative Stress in Toxicology and Disease'was the subject of a symposium
held at the EUROTOX meeting in Dresden 15th September 2009. Reactive oxygen (ROS) …
held at the EUROTOX meeting in Dresden 15th September 2009. Reactive oxygen (ROS) …
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
Chronic manganese (Mn) exposure induces neurotoxicity, which is characterized by
Parkinsonian symptoms resulting from impairment in the extrapyramidal motor system of the …
Parkinsonian symptoms resulting from impairment in the extrapyramidal motor system of the …
Inflammatory activation of microglia and astrocytes in manganese neurotoxicity
RB Tjalkens, KA Popichak, KA Kirkley - Neurotoxicity of Metals, 2017 - Springer
Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early
as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1: 41–42, 1837). Extensive research …
as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1: 41–42, 1837). Extensive research …
Manganese accumulation in the brain via various transporters and its neurotoxicity mechanisms
I Nyarko-Danquah, E Pajarillo, A Digman, KFA Soliman… - Molecules, 2020 - mdpi.com
Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …
New insights on the role of manganese in Alzheimer's disease and Parkinson's disease
Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …
is necessary as a cofactor for many enzymes and is important in several physiological …