Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Disclosures: P. Izmirly reported personal fees from GlaxoSmithKline outside the submitted
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …

Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous
autoimmune disease. The etiology of lupus and the contribution of genetic, environmental …

Most acute strokes are ischemic, and subsequent neuroinflammation promotes further
damage leading to cell death but also plays a beneficial role by promoting cellular repair …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

In recent years, neutrophil extracellular traps at the forefront of neutrophil biology have
proven to help capture and kill pathogens involved in the inflammatory process. There is …

Membranous nephropathy (MN) is a common cause of proteinuria and nephrotic syndrome
all over the world. It can be subdivided into primary and secondary forms. Primary form is an …