Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …

Detection of mismatched human leukocyte antigens by adaptive immune cells is considered
as the main cause of transplant rejection, leading to either T-cell mediated rejection or …

Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …

Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …

The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the
serum of thousands of donors and were initially used as an IgG replacement therapy in …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …

The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial
processes for eliciting an effective adaptive host response to the majority of pathogens. The …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …