Neurobiology of chronic mild stress: parallels to major depression
MN Hill, KGC Hellemans, P Verma, BB Gorzalka… - Neuroscience & …, 2012 - Elsevier
The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …
animal model of depression more than 20 years ago. The foundation of this model was that …
Exploring the role of neuropeptides in depression and anxiety
Depression is one of the most prevalent forms of mental disorders and is the most common
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …
Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder
Converging evidence implicates the regulatory neuropeptide Y (NPY) in anxiety-and
depression-related behaviors. The present study sought to assess whether there is an …
depression-related behaviors. The present study sought to assess whether there is an …
The role of substance P in stress and anxiety responses
K Ebner, N Singewald - Amino acids, 2006 - Springer
Substance P (SP) is one of the most abundant peptides in the central nervous system and
has been implicated in a variety of physiological and pathophysiological processes …
has been implicated in a variety of physiological and pathophysiological processes …
Neuropeptide and small transmitter coexistence: fundamental studies and relevance to mental illness
Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …
Hippocampus: molecular, cellular, and circuit features in anxiety
HJ Shi, S Wang, XP Wang, RX Zhang, LJ Zhu - Neuroscience bulletin, 2023 - Springer
Anxiety disorders are currently a major psychiatric and social problem, the mechanisms of
which have been only partially elucidated. The hippocampus serves as a major target of …
which have been only partially elucidated. The hippocampus serves as a major target of …
Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal‐ventral and region‐specific differences
Major depressive disorder is a common and complex mental disorder with unknown
etiology. GABAergic dysfunction is likely to contribute to the pathophysiology since disrupted …
etiology. GABAergic dysfunction is likely to contribute to the pathophysiology since disrupted …
[HTML][HTML] Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress
Chronic stress is closely linked to clinical depression, which could be assessed by a chronic
unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based …
unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based …
The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus
S Thakker-Varia, JJ Krol, J Nettleton… - Journal of …, 2007 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by
antidepressant treatments, and BDNF produces antidepressant-like effects in behavioral …
antidepressant treatments, and BDNF produces antidepressant-like effects in behavioral …