Abstract The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is crucial to many
aspects of cell growth, survival and apoptosis, and its constitutive activation has been …

The p53-related genes p63 and p73 exhibit significant structural homology to p53; however,
they do not function as classical tumor suppressors and are rarely mutated in human …

Since cancer is one of the leading causes of death worldwide, there is an urgent need to find
better treatments. Currently, the use of chemotherapeutics remains the predominant option …

Molecular links between apoptosis, tumorigenesis and drug resistance provide starting
points for new therapeutic approaches and for a targeted cancer therapy. The discovery of …

Abstract MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-
transcriptionally, are involved in many complex cellular processes. Several miRNAs are …

In a significant number of cases cancer therapy is followed by a resurgence of more
aggressive tumors derived from immature cells. One example is acute myeloid leukemia …

The p53 tumor suppressor is part of a small family of related proteins that includes two other
members, p73 and p63. Interest in the p53 family members, their functions and their complex …

The p53 family proteins carry on a wide spectrum of biological functions from differentiation,
cell cycle arrest, apoptosis, and chemosensitivity of tumors. NH2-terminally truncated p73 …

The P73 gene is a homologue of the P53 tumor suppressor. Owing to its structural similarity
with p53, p73 was originally considered to have tumor suppressor function. However, the …

TP73 is a member of the TP53 family whose expression has been observed altered in most
human cancers and associated with the prognosis. TP73 translates into a complex number …