Congenital heart defects (CHDs) are common human birth defects. Genetic mutations
potentially cause the exhibition of various pathological phenotypes associated with CHDs …

Heterozygous missense variants in TRAF7 lead to various cancers when somatic and a
multiple congenital anomalies--intellectual disability syndrome (MCA-IDS) when germline …

While somatic driver gene mutations are considered the hallmark of cancer, oncogenic
mutations have recently been found in non-diseased proliferative tissues, such as …

TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal
transduction pathways, contributing to immune responses, tumor progression, and …

We are in receipt of Pisan et al.'s letter (1). Our manuscript (2) reported the association of p.
Val142Met, p. Val442Met, and c. 1998+ 2T> G TRAF7 variants with congenital heart disease …

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections in the
USA and of preventable blindness worldwide. This obligate intracellular pathogen replicates …

Approximately half of the cases of chronic kidney disease (CKD) in childhood are caused by
congenital anomalies of the kidney and urinary tract (CAKUT). Specific genes were …

Therapeutic use of tiny extracellular vesicles (EVs) requires understanding cargo loading
mechanisms. Here, we used a modular proximity label approach to identify EV cargo …