While type I interferons (IFNs) are universally acknowledged for their antiviral and
immunostimulatory functions, there is increasing appreciation of the detrimental effects of …

The influenza A virus is one of the leading causes of respiratory tract infections in humans.
Upon infection with an influenza A virus, both innate and adaptive immune responses are …

The microbiota is known to modulate the host response to influenza infection through as-yet-
unclear mechanisms. We hypothesized that components of the microbiota exert effects …

Influenza symptoms vary from mild disease to death; however, determinants of severity are
unclear. Type I interferons (IFNαβ) are recognized as key antiviral cytokines. Here we show …

Rationale: Patients who developed acute respiratory distress syndrome (ARDS) after
infection with severe respiratory viruses (eg, severe acute respiratory syndrome …

Influenza viruses cause acute respiratory inflammation in humans and symptoms such as
high fever, body aches, and fatigue. Usually these symptoms improve after several days; …

Observational data suggest that the treatment of influenza infection with neuraminidase
inhibitors decreases progression to more severe illness, especially when treatment is started …

Type I interferon (IFN-I) plays a critical role in the homeostasis of hematopoietic stem cells
and influences neutrophil influx to the site of inflammation. IFN-I receptor knockout …

Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of
humans remains inefficient, many of those with H5N1 disease have a rapidly progressing …

Influenza viruses are globally important human respiratory pathogens. These viruses cause
seasonal epidemics and occasional worldwide pandemics, both of which can vary …