Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

In the developing brain, dendrite branches and dendritic spines form and turn over
dynamically. By contrast, most dendrite arbors and dendritic spines in the adult brain are …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

In the past 15 years numerous reports provided strong evidence that brain-derived
neurotrophic factor (BDNF) is one of the most important modulators of glutamatergic and …

Nascent proteins can be positioned rapidly at precise subcellular locations by local protein
synthesis (LPS) to facilitate localized growth responses. Axon arbor architecture, a major …

Brain-derived neurotrophic factor (BDNF) attracts increasing attention from both research
and clinical fields because of its important functions in the central nervous system. An …

Astrocytes are a heterogeneous population of neural cells with diverse structural, functional
and molecular characteristics responsible for homeostasis and protection of the central …

Emerging evidence indicates that once established, synapses and dendrites can be
maintained for long periods, if not for the organism's entire lifetime. In contrast to the wealth …

The tropomyosin-related tyrosine kinase (Trk) receptors were initially described as a family
of growth factor receptors required for neuronal survival. They have since been shown to …