Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review
S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
Considerations for the use of phage therapy in clinical practice
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …
renewed interest in phage therapy as an alternative or adjunct to conventional …
[HTML][HTML] Acinetobacter baumannii Antibiotic Resistance Mechanisms
Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to
public health by causing severe and invasive (mostly nosocomial) infections linked with high …
public health by causing severe and invasive (mostly nosocomial) infections linked with high …
[HTML][HTML] Acinetobacter baumannii Infections in Times of COVID-19 Pandemic
K Rangel, TPG Chagas, SG De-Simone - Pathogens, 2021 - mdpi.com
The COVID-19 pandemic has generated an overuse of antimicrobials in critically ill patients.
Acinetobacter baumannii frequently causes nosocomial infections, particularly in intensive …
Acinetobacter baumannii frequently causes nosocomial infections, particularly in intensive …
Novel antimicrobial agents for combating antibiotic-resistant bacteria
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …
[HTML][HTML] Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …
consideration for commercial development of phages for phage therapy is the number of …
[HTML][HTML] Translating phage therapy into the clinic: recent accomplishments but continuing challenges
A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …
[HTML][HTML] Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study
Background Clinical phage therapy is often delivered alongside antibiotics. However, the
phenomenon of phage-antibiotic synergy has been mostly studied in vitro. Here, we …
phenomenon of phage-antibiotic synergy has been mostly studied in vitro. Here, we …
[HTML][HTML] Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit
Y Jiang, Y Ding, Y Wei, C Jian, J Liu… - Frontiers in microbiology, 2022 - frontiersin.org
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become one of the leading
causes of healthcare-associated infections globally, particularly in intensive care units …
causes of healthcare-associated infections globally, particularly in intensive care units …
[HTML][HTML] The safety and efficacy of phage therapy: a systematic review of clinical and safety trials
HJ Stacey, S De Soir, JD Jones - Antibiotics, 2022 - mdpi.com
Trials of phage therapy have not consistently reported efficacy. This contrasts with promising
efficacy rates from a sizeable and compelling body of observational literature. This …
efficacy rates from a sizeable and compelling body of observational literature. This …