Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Current in vitro gut models lack physiological relevance, and various approaches have been
taken to improve current cell culture models. For example, mimicking the three-dimensional …

The bioavailability of drugs from oral formulations is influenced by many physiological
factors including gastrointestinal fluid composition, pH and dynamics, transit and motility …

Objective Although the human small intestine serves primarily as an absorptive organ for
nutrients and water, it also has the ability to metabolise drugs. Interest in the small intestine …

After oral intake of drugs, drugs go through the first pass metabolism in the gut and the liver,
which greatly affects the final outcome of the drugs' efficacy and side effects. The first pass …

Intestinal first-pass metabolism may contribute to low oral drug bioavailability and drug-drug
interactions, particularly for CYP3A substrates. The current analysis predicted intestinal …

The purpose of this study was to evaluate the use of human intestinal tissue in Ussing
chamber to predict oral and colonic drug absorption and intestinal metabolism. Data on …

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (eg intestinal CYP3A abundance in the intestine is 1% that of the liver) …

This work revises and complements existing findings on the distribution of drug‐
metabolizing enzymes in the first‐pass effect organs. We explored gene expression …