A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Concise review: MSC-derived exosomes for cell-free therapy

DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …

Exosome-based cell-cell communication in the tumor microenvironment

J Maia, S Caja, MC Strano Moraes, N Couto… - Frontiers in cell and …, 2018 - frontiersin.org
Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …

Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and …

M Pomatto, C Gai, F Negro, M Cedrino… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stem cells isolated from both bone
marrow (BMSCs) and adipose tissue (ADSCs) show potential therapeutic effects. These …

Isolation, cultivation, and characterization of human mesenchymal stem cells

D Mushahary, A Spittler, C Kasper, V Weber… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSC) exhibit a high self‐renewal capacity, multilineage
differentiation potential and immunomodulatory properties. This set of exceptional features …

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …

M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …

Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells

Z Wang, Z He, S Liang, Q Yang, P Cheng… - Stem Cell Research & …, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive
application prospects over the years. Despite performing similar functions, exosomes from …