[HTML][HTML] The Hippo signalling pathway and its implications in human health and diseases

M Fu, Y Hu, T Lan, KL Guan, T Luo… - Signal transduction and …, 2022 - nature.com
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

[HTML][HTML] An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases

X Wei, G Huang, J Liu, J Ge, W Zhang, Z Mei - Biomedicine & …, 2023 - Elsevier
The most frequent reason of morbidity and mortality in the world, cerebral ischemia sets off a
chain of molecular and cellular pathologies that associated with some central nervous …

[HTML][HTML] N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye

P Deshpande, AV Chimata, E Snider, A Singh… - Cell Death & …, 2023 - nature.com
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests as
accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of …

[HTML][HTML] Mitogen-activated protein kinase pathway in amyotrophic lateral sclerosis

TG Sahana, K Zhang - Biomedicines, 2021 - mdpi.com
Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease. Multiple genetic
and non-genetic risk factors are associated with disease pathogenesis, and several cellular …

Neuronal Hippo signaling: From development to diseases

MR Sahu, AC Mondal - Developmental neurobiology, 2021 - Wiley Online Library
Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily
dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein …

[HTML][HTML] Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges

L Zhu, S Li, XJ Li, P Yin - Translational neurodegeneration, 2023 - Springer
In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and
progressive neurodegenerative disease with heterogeneous clinical presentations …

Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers

F Liguori, S Amadio, C Volonté - Cellular and Molecular Life Sciences, 2021 - Springer
Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement
impairment, respiratory failure and ultimate death. A plethora of genetic, cellular and …

[HTML][HTML] Pathophysiology of stress granules: An emerging link to diseases

J Wang, Y Gan, J Cao, X Dong… - … Journal of Molecular …, 2022 - spandidos-publications.com
Under unfavorable environmental conditions, eukaryotic cells may form stress granules
(SGs) in the cytosol to protect against injury and promote cell survival. The initiation, mRNA …

[HTML][HTML] Where and why modeling amyotrophic lateral sclerosis

F Liguori, S Amadio, C Volonté - International Journal of Molecular …, 2021 - mdpi.com
Over the years, researchers have leveraged a host of different in vivo models in order to
dissect amyotrophic lateral sclerosis (ALS), a neurodegenerative/neuroinflammatory …

FUS mutation is probably the most common pathogenic gene for JALS, especially sporadic JALS

L Chen - Revue Neurologique, 2021 - Elsevier
Juvenile amyotrophic lateral sclerosis (JALS) is a rare and severe form of ALS. The
development of gene sequencing methods has resulted in increased reports of JALS cases …