It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Highlights•An unprecedented number of peptide therapeutics have recently been
approved.•Clinical pipeline analysis reveals an emphasis on peptides with enhanced …

Macrocycles occupy a unique segment of chemical space. In the past decade, their chemical
diversity expanded significantly, supported by advances in bioinformatics and synthetic …

Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …

The movement of core-lipopolysaccharide across the inner membrane of Gram-negative
bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. Recent …

Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it
is responsible for barrier function,. LPS can cause death as a result of septic shock, and its …

Molecular docking is the methodology of choice for studying in silico protein-ligand binding
and for prioritizing compounds to discover new lead candidates. Traditional docking …

Dengue virus (DENV) infection causes serious health problems in humans for which no drug
is currently available. Recently, DENV NS2B-NS3 protease has been proposed as a primary …

Zero-dimensional graphitic carbon nitride nanoparticles (0D gC 3 N 4 NPs) possess the
advantages of non-toxicity, metal-free, and rich surface catalytic active sites. However, the …

Secamone afzelii (Roem. & Schult.) K. Schum (family Asclepiadaceae) is a creeping woody
climber used to treat ailments in many traditional medicine systems. The present study aims …