Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics
Objectives The aim of this research was to review the literature on Alzheimer's disease (AD)
with a focus on polyphenolics as antioxidant therapeutics. Design This review included a …
with a focus on polyphenolics as antioxidant therapeutics. Design This review included a …
Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress
Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …
over 30 million people globally. Currently, no effective treatment is available due to multiple …
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
worldwide, has brought enormous challenge to the society. Due to its extremely complex …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology
C Albertini, A Salerno… - Medicinal Research …, 2021 - Wiley Online Library
The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …
Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism
S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …
several diseases are discussed here. Pure human BChE has been proved safe and effective …
Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice
C Wang, X Cai, R Wang, S Zhai, Y Zhang, W Hu… - Journal of …, 2020 - Springer
Background Endoplasmic reticulum (ER) stress is involved in the progression of Alzheimer's
disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated …
disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated …
Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation
Multifactorial neurodegenerative disorders such as Alzheimer's disease (AD) are considered
a growing public health problem due the rising incidence and low effectiveness of current …
a growing public health problem due the rising incidence and low effectiveness of current …
Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents
Alzheimer's disease (AD) is a neurological disorder that leads to dementia ie, progressive
memory loss accompanied with worsening of thinking ability of an individual. The cause of …
memory loss accompanied with worsening of thinking ability of an individual. The cause of …
Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease
Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1, 3, 4-oxadiazoles
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …
were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested …