TEER measurement techniques for in vitro barrier model systems
Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …
quantitative technique to measure the integrity of tight junction dynamics in cell culture …
In-vitro blood-brain barrier models for drug screening and permeation studies: an overview
The blood-brain barrier (BBB) is comprised of brain microvascular endothelial central
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …
A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier
The neurovascular unit is a complex, interdependent system composed of neurons and
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …
Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease
X Cong, W Kong - Cellular signalling, 2020 - Elsevier
Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …
Recent advances in the prediction of pharmacokinetics properties in drug design studies: a review
SQ Pantaleão, PO Fernandes, JE Gonçalves… - …, 2022 - Wiley Online Library
This review presents the main aspects related to pharmacokinetic properties, which are
essential for the efficacy and safety of drugs. This topic is very important because the …
essential for the efficacy and safety of drugs. This topic is very important because the …
Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review
During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …
there is a considerable attrition rate caused by their hampered access to the brain by the …
Design and validation of liposomal ApoE2 gene delivery system to evade blood–brain barrier for effective treatment of Alzheimer's disease
Targeting gene-based therapeutics to the brain is a strategy actively sought to treat
Alzheimer's disease (AD). Recent findings discovered the role of apolipoprotein E (ApoE) …
Alzheimer's disease (AD). Recent findings discovered the role of apolipoprotein E (ApoE) …
Trojan horse transit contributes to blood-brain barrier crossing of a eukaryotic pathogen
The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …
passage of molecules and microorganisms. Despite this barrier, however, the fungal …
In vitro blood brain barrier models: An overview
E Jagtiani, M Yeolekar, S Naik, V Patravale - Journal of Controlled Release, 2022 - Elsevier
Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …
development of novel, innovative techniques for administering central nervous system …
Benchmarking in vitro tissue-engineered blood–brain barrier models
JG DeStefano, JJ Jamieson, RM Linville… - Fluids and Barriers of …, 2018 - Springer
The blood–brain barrier (BBB) plays a key role in regulating transport into and out of the
brain. With increasing interest in the role of the BBB in health and disease, there have been …
brain. With increasing interest in the role of the BBB in health and disease, there have been …