Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
Gene–environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta‐analyses of observational studies
The cause of colorectal cancer (CRC) is multifactorial, involving both genetic variants and
environmental risk factors. We systematically searched the MEDLINE, EMBASE, China …
environmental risk factors. We systematically searched the MEDLINE, EMBASE, China …
Novel common genetic susceptibility loci for colorectal cancer
Background Previous genome-wide association studies (GWAS) have identified 42 loci (P<
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …
5× 10− 8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
Risk stratification for early-onset colorectal cancer using a combination of genetic and environmental risk scores: an international multi-center study
Background The incidence of colorectal cancer (CRC) among individuals aged younger
than 50 years has been increasing. As screening guidelines lower the recommended age of …
than 50 years has been increasing. As screening guidelines lower the recommended age of …
[HTML][HTML] Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis
Background While dietary fat has been established as a risk factor for colorectal cancer
(CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using …
(CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using …
Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study
Background Whilst observational studies establish that lower plasma 25-hydroxyvitamin D
(25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing …
(25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing …
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
Background Menopausal hormone therapy (MHT), a common treatment to relieve symptoms
of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC …
of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC …
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
P Pihán, F Lisbona, J Borgonovo… - Science …, 2021 - science.org
Programmed cell death is regulated by the balance between activating and inhibitory
signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress …
signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress …