Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis

D Suwei, X Yanbin, W Jianqiang, M Xiang… - Cellular & Molecular …, 2022 - Springer
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is
urgent to find novel therapy strategies to overcome this feature. Metformin has been …

SPINKs in tumors: potential therapeutic targets

C Liao, Q Wang, J An, M Zhang, J Chen, X Li… - Frontiers in …, 2022 - frontiersin.org
The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the
largest branch in the serine protease inhibitor family. SPINKs play an important role in …

SPINK5 is a prognostic biomarker associated with the progression and prognosis of laryngeal squamous cell carcinoma identified by weighted gene co-expression …

J Liu, J Zhao, J Xu, Q Sun, X Qin… - Evolutionary …, 2022 - journals.sagepub.com
Laryngeal squamous cell carcinoma (LSCC) is one of the most common types of head and
neck squamous cell carcinomas (HNSCC) and is the second most prevalent malignancy …

Epithelial–mesenchymal transition inhibition by metformin reduces melanoma lung metastasis in a murine model

ES Veloso, BA de Carvalho, FH de Souza Silva… - Scientific Reports, 2022 - nature.com
Melanoma is an aggressive cancer with fast metastatic spread and reduced survival time.
One common event during the neoplastic progression is the epithelial–mesenchymal …

CEBPB knockdown sensitizes nasopharyngeal carcinoma cells to cisplatin by promoting the expression of serine protease inhibitor Kazal-type 5

H Liu, Q Huang, Y Lv, Y Dong, D Song - Anti-Cancer Drugs, 2022 - journals.lww.com
Serine protease inhibitor Kazal-type 5 (SPINK5) has been indicated to act as a prognostic
predictor for patients with head and neck squamous cell carcinoma. However, its specific …

SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity

J Chen, J Lu, Z Chen, Z Liu, Y Sun, S He… - The Journal of Gene …, 2024 - Wiley Online Library
Background Esophageal squamous cell carcinoma (ESCC) is a predominant subtype of
esophageal cancer with relatively high mortality worldwide. Serine peptidase inhibitor Kazal …

Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma

X Abuduhadeer, X Xu, K Aihesan… - Journal of Clinical …, 2021 - Wiley Online Library
Backgrounds Gastric cancer is one of the most common cancers with unsatisfied prognosis.
It is challenging to predict gastric cancer prognosis due to its highly heterogeneous nature …

Kallikrein 5 inhibition by the lympho-epithelial kazal-type related inhibitor hinders matriptase-dependent carcinogenesis

EZM da Silva, TFC Fraga-Silva, Y Yuan, MG Alves… - Cancers, 2021 - mdpi.com
Simple Summary Head and neck squamous cell carcinomas (HNSCC) are among the most
common cancers worldwide. In contrast to the advances in prevention and treatment of other …

Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple‐negative breast cancer

Y Song, G Bai, X Li, L Zhou, Y Si, X Liu… - Cancer …, 2023 - Wiley Online Library
Background Metaplastic breast carcinoma (MBC) is a rare breast cancer subtype; most
cases are triple‐negative breast cancers (TNBCs) and are poorly responsive to conventional …

Kallikrein 5 inhibition by the Lympho-epithelial Kazal-type related inhibitor hinders matriptase-dependent carcinogenesis

EZM Silva, TFC Fraga-Silva, Y Yuan, MG Alves… - Cancers, 2021 - repositorio.usp.br
USP affiliated authors: MARCELINO, ELAINE ZAYAS-FMRP; FONSECA, CAROL KOBORI
DA-FMRP; SILVA, ALFREDO RIBEIRO DA-FMRP; ALVES FILHO, JOSÉ CARLOS FARIAS …