Mesial temporal lobe epilepsy (MTLE), the most common epilepsy in adults, is generally
intractable and is suspected to be the result of recurrent excitation or inhibition circuitry …

Introduction: There are three phases of seizure developing in pentylenetetrazol (PTZ)-
induced kindling animal model:(i) pre-kindling phase;(ii) kindling phase or after animals are …

NEURONAL degeneration in the hippocampus, a region of the brain important for
acquisition of memory in humans, occurs in various pathological conditions, including …

Whereas neonatal seizures are a predictor of adverse neurological outcome, there is
controversy regarding whether seizures simply reflect an underlying brain injury or can …

Epilepsy is a common outcome of traumatic brain injury (TBI), but the mechanisms of
posttraumatic epileptogenesis are poorly understood. One clue is the occurrence of …

Seizure-induced sprouting of the mossy fiber pathway in the dentate gyrus has been
observed nearly universally in experimental models of limbic epilepsy and in the epileptic …

In some children, epilepsy is a catastrophic condition, leading to significant intellectual and
behavioral impairment, but little is known about the consequences of recurrent seizures …

One of the oldest questions in epilepsy is whether seizures are a cause or a result of brain
damage. Animal data have provided us with insights into the relationship between seizures …

Mossy fiber sprouting is a form of synaptic reorganization in the dentate gyrus that occurs in
human temporal lobe epilepsy and animal models of epilepsy. The axons of dentate gyrus …

Purpose: To study the development of epilepsy following hypoxia‐induced neonatal
seizures in Long‐Evans rats and to establish the presence of spontaneous seizures in this …