The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

With laboratories seeking to expand analytical capabilities and create multi-class, multi-
analyte methods, there has been a shift toward generic sample clean-up techniques such as …

Aging alters the amplitude and phase of centrally regulated circadian rhythms. Here we
evaluate whether peripheral circadian rhythmicity in the plasma lipidome is altered by aging …

Circadian clocks coordinate mammalian behavior and physiology enabling organisms to
anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive …

Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Daily (circadian) rhythms coordinate our physiology and behaviour with regular
environmental changes. Molecular clocks in peripheral tissues (eg liver, skeletal muscle and …

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of
the mechanisms involved have focused largely on acute sleep deprivation. 1, 2 To identify …

Context Studies suggest that female reproductive hormones are under circadian regulation,
although methodological differences have led to inconsistent findings. Objective To …

Sleep deprivation enhances risk for serious injury and fatality on the roads and in
workplaces. To facilitate future management of these risks through advanced detection, we …

Misalignment of the daily sleep-wake and fasting-feeding cycles with the endogenous
circadian timing system is an inevitable consequence of night shift work and is associated …