[HTML][HTML] Reinforcement learning for clinical decision support in critical care: comprehensive review

S Liu, KC See, KY Ngiam, LA Celi, X Sun… - Journal of medical Internet …, 2020 - jmir.org
Background Decision support systems based on reinforcement learning (RL) have been
implemented to facilitate the delivery of personalized care. This paper aimed to provide a …

Causal inference using observational intensive care unit data: a scoping review and recommendations for future practice

JM Smit, JH Krijthe, WMR Kant, JA Labrecque… - npj Digital …, 2023 - nature.com
This scoping review focuses on the essential role of models for causal inference in shaping
actionable artificial intelligence (AI) designed to aid clinicians in decision-making. The …

Online identification of pharmacodynamic parameters for closed-loop anesthesia with model predictive control

B Aubouin–Pairault, M Fiacchini, T Dang - Computers & Chemical …, 2024 - Elsevier
In this paper, a controller is proposed to automate the injection of propofol and remifentanil
during general anesthesia using bispectral index (BIS) measurement. To handle the …

A nonovershooting tracking controller for simultaneous infusion of anesthetics and analgesics

R Padmanabhan, N Meskin, CM Ionescu… - … Signal Processing and …, 2019 - Elsevier
In this paper, a nonovershooting tracking controller is proposed for the continuous infusion
of multiple drugs that have interactive effects. The proposed controller design method …

Automated multi-drugs administration during total intravenous anesthesia using multi-model predictive control

B Aubouin-Pairault, M Fiacchini, T Dang - arXiv preprint arXiv:2309.08229, 2023 - arxiv.org
In this paper, a multi-model predictive control approach is used to automate the co-
administration of propofol and remifentanil from bispectral index measurement during …

A PopPBPK-RL approach for precision dosing of benazepril in renal impaired patients

G Vigueras, L Muñoz-Gil, V Reinisch… - … of Pharmacokinetics and …, 2025 - Springer
Current treatment recommendations mainly rely on rule-based protocols defined from
evidence-based clinical guidelines, which are difficult to adapt for high-risk patients such as …

Reinforcement Learning in Personalized Medicine

H Yang, H Fu - Data Science, AI, and Machine Learning in Drug …, 2022 - taylorfrancis.com
This chapter provides an overview of the advances in personalized medicine aided by
reinforcement learning (RL). Precision medicine is intended to match targeted therapies to a …

Rapid Nonovershooting Control for Simultaneous Infusion of Anesthetics and Analgesics

C Wang, Y Liu, R Schmid - IFAC-PapersOnLine, 2021 - Elsevier
We propose a rapid nonovershooting tracking controller for the continuous infusion of
anesthetics and analgesics to prevent overdosing and other harmful side effects on patients …

Predicting optimal sedation control with reinforcement learning

A Vajapey - 2019 - dspace.mit.edu
Administering sedation to patients to avoid underdosing and overdosing is an important
clinical task that remains hard to control due to lack of precision in current methods of …

aDepartment of Electrical Engineering, Qatar University, Doha, Qatar, bSchool of Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA, United States

R Padmanabhan, N Meskin… - Control Applications for …, 2020 - books.google.com
This chapter presents a general framework that utilizes reinforcement learning (RL)-based
method to regulate multiple parameters during intravenous drug administration. First, the Q …