Physiology of weight regain: Lessons from the classic Minnesota Starvation Experiment on human body composition regulation

AG Dulloo - Obesity Reviews, 2021 - Wiley Online Library
Since its publication in 1950, the Biology of Human Starvation, which describes the classic
longitudinal Minnesota Experiment of semistarvation and refeeding in healthy young men …

Single‐leg disuse decreases skeletal muscle strength, size, and power in uninjured adults: a systematic review and meta‐analysis

N Preobrazenski, J Seigel, S Halliday… - Journal of cachexia …, 2023 - Wiley Online Library
We aimed to quantify declines from baseline in lower limb skeletal muscle size and strength
of uninjured adults following single‐leg disuse. We searched EMBASE, Medline, CINAHL …

[HTML][HTML] Vegan and omnivorous high protein diets support comparable daily myofibrillar protein synthesis rates and skeletal muscle hypertrophy in young adults

AJ Monteyne, MOC Coelho, AJ Murton… - The Journal of …, 2023 - Elsevier
Background It remains unclear whether non–animal-derived dietary protein sources (and
therefore vegan diets) can support resistance training-induced skeletal muscle remodeling …

Signatures of muscle disuse in spaceflight and bed rest revealed by single muscle fiber proteomics

M Murgia, S Ciciliot, N Nagaraj, C Reggiani… - PNAS …, 2022 - academic.oup.com
Astronauts experience dramatic loss of muscle mass, decreased strength, and insulin
resistance, despite performing daily intense physical exercise that would lead to muscle …

Short‐term disuse does not affect postabsorptive or postprandial muscle protein fractional breakdown rates

GF Pavis, DR Abdelrahman, AJ Murton… - Journal of cachexia …, 2023 - Wiley Online Library
Background The decline in postabsorptive and postprandial muscle protein fractional
synthesis rates (FSR) does not quantitatively account for muscle atrophy during …

Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading

VC Figueiredo, RF D'Souza… - Journal of cachexia …, 2021 - Wiley Online Library
Background Translational capacity (ie ribosomal mass) is a key determinant of protein
synthesis and has been associated with skeletal muscle hypertrophy. The role of …

A mycoprotein-based high-protein vegan diet supports equivalent daily myofibrillar protein synthesis rates compared with an isonitrogenous omnivorous diet in older …

AJ Monteyne, MV Dunlop, DJ Machin… - British journal of …, 2021 - cambridge.org
Animal-derived dietary protein ingestion and physical activity stimulate myofibrillar protein
synthesis rates in older adults. We determined whether a non-animal-derived diet can …

Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading‐dependent changes linked to muscle atrophy

M Murgia, L Brocca, E Monti, MV Franchi… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Inactivity and unloading induce skeletal muscle atrophy, loss of strength and
detrimental metabolic effects. Bed rest is a model to study the impact of inactivity on the …

Muscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men

TSO Jameson, SP Kilroe, J Fulford… - American Journal …, 2021 - journals.physiology.org
Short-term disuse leads to muscle loss driven by lowered daily myofibrillar protein synthesis
(MyoPS). However, disuse commonly results from muscle damage, and its influence on …

A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states

IA Ely, BE Phillips, K Smith, DJ Wilkinson, M Piasecki… - Clinical Nutrition, 2023 - Elsevier
Muscle protein synthesis (MPS) and muscle protein breakdown (MPB) are influenced
through dietary protein intake and physical (in) activity, which it follows, regulate skeletal …