The T cell immune response against SARS-CoV-2

P Moss - Nature immunology, 2022 - nature.com
The adaptive immune response is a major determinant of the clinical outcome after SARS-
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …

COVID-19 vaccine development: milestones, lessons and prospects

M Li, H Wang, L Tian, Z Pang, Q Yang… - Signal transduction and …, 2022 - nature.com
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

RR Goel, MM Painter, SA Apostolidis, D Mathew… - Science, 2021 - science.org
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …

The germinal centre B cell response to SARS-CoV-2

BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …

Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?

SJ Kent, DS Khoury, A Reynaldi, JA Juno… - Nature Reviews …, 2022 - nature.com
The rapid development of multiple vaccines providing strong protection from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …

SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine

R Kotaki, Y Adachi, S Moriyama, T Onodera… - Science …, 2022 - science.org
Multiple SARS-CoV-2 variants have mutations in the spike receptor binding domain (RBD)
with potential to evade neutralizing antibody. In particular, the Beta and Omicron variants …

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells

AA Minervina, MV Pogorelyy, AM Kirk, JC Crawford… - Nature …, 2022 - nature.com
Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high,
variant emergence has prompted booster immunizations. However, the effects of repeated …

Effectiveness of the BNT162b2 vaccine after recovery from Covid-19

A Hammerman, R Sergienko, M Friger… - … England Journal of …, 2022 - Mass Medical Soc
Background The risk of infection with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) decreases substantially among patients who have recovered from …

[HTML][HTML] T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre …

A Angyal, S Longet, SC Moore, RP Payne… - The Lancet …, 2022 - thelancet.com
Background Previous infection with SARS-CoV-2 affects the immune response to the first
dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and …

COVID-19 vaccination in pregnancy, paediatrics, immunocompromised patients, and persons with history of allergy or prior SARS-CoV-2 infection: overview of current …

N Luxi, A Giovanazzi, A Capuano, S Crisafulli… - Drug safety, 2021 - Springer
To date, four vaccines have been authorised for emergency use and under conditional
approval by the European Medicines Agency to prevent COVID-19: Comirnaty, COVID-19 …