The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

▪ Abstract Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of
the eukaryotic cell division cycle and have also been implicated in the control of gene …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Filamentous fungi are unique organisms—rivaled only by actinomycetes and plants—in
producing a wide range of natural products called secondary metabolites. These …

Glucose and related sugars repress the transcription of genes encoding enzymes required
for the utilization of alternative carbon sources; some of these genes are also repressed by …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

Genome-wide expression analysis was used to identify genes whose expression depends
on the functions of key components of the transcription initiation machinery in yeast …

The HIV-1 Tat protein regulates transcription elongation through binding to the viral TAR
RNA stem-loop structure. We have isolated a novel 87 kDa cyclin C–related protein (cyclin …

Systemic acquired resistance (SAR) is a broad-spectrum plant immune response involving
profound transcriptional changes that are regulated by the coactivator NPR1. Nuclear …