Impaired dopamine metabolism in Parkinson's disease pathogenesis

A Masato, N Plotegher, D Boassa… - Molecular …, 2019 - Springer
A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Animal models of depression: what can they teach us about the human disease?

M Becker, A Pinhasov, A Ornoy - Diagnostics, 2021 - mdpi.com
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions

A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson's disease

J Song, L Liu, Z Li, T Mao, J Zhang, L Zhou, X Chen… - BMC medicine, 2022 - Springer
Background Parkinson's disease (PD) is the second most common neurodegenerative
disease in middle-aged and elderly populations, whereas there is no cure for PD so far …

Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects

C Carnovale, C Perrotta, S Baldelli… - Cardiovascular …, 2023 - academic.oup.com
A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

Repeated reserpine treatment induces depressive-like behaviors accompanied with hippocampal impairment and synapse deficit in mice

X Qian, Z Zhong, S Lu, Y Zhang - Brain Research, 2023 - Elsevier
Depression remains a significant public health concern, and current animal models of
depression are limited in their ability to accurately mimic human depression. However …

Female rats are resistant to cognitive, motor and dopaminergic deficits in the reserpine-induced progressive model of Parkinson's disease

AC Lima, YSR Meurer, VS Bioni… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
main symptoms are motor signs such as resting tremor and difficulty in initializing …

Cannabidiol prevents motor and cognitive impairments induced by reserpine in rats

FF Peres, R Levin, MA Suiama, MC Diana… - Frontiers in …, 2016 - frontiersin.org
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents
antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's …

Neurotoxin-induced rodent models of Parkinson's disease: benefits and drawbacks

M El-Gamal, M Salama, LE Collins-Praino, I Baetu… - Neurotoxicity …, 2021 - Springer
Abstract Parkinson's disease (PD), the second most common neurodegenerative disorder, is
characterized by cardinal motor impairments, including akinesia and tremor, as well as by a …

Preclinical reserpine models recapitulating motor and non-motor features of Parkinson's disease: Roles of epigenetic upregulation of alpha-synuclein and autophagy …

Y Li, Q Yin, B Wang, T Shen, W Luo, T Liu - Frontiers in pharmacology, 2022 - frontiersin.org
Reserpine is an effective drug for the clinical treatment of hypertension. It also induces
Parkinson's disease (PD)-like symptoms in humans and animals possible through the …