Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

The function of somatic stem cells declines with age. Understanding the molecular
underpinnings of this decline is key to counteract age-related disease. Here, we report a …

Proliferative thyroid diseases are more prevalent in females than in males. Upon the onset of
puberty, the incidence of thyroid cancer increases in females only and declines again after …

Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods
of regeneration, degeneration, and rest throughout adult life in mammals. The crucial …

The prominent role of CD44 in tumor cell signaling together with its establishment as a
cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC …

Defining the unique molecular features of progenitors and their niche requires a genome-
wide, whole-tissue approach with cellular resolution. Here, we co-isolate embryonic hair …

The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study
stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla …

Aging is characterized by a progressive decline of physiological integrity leading to the loss
of tissue function and vulnerability to disease, but its causes remain poorly understood …

Human endometrium undergoes cyclic regeneration involving stem/progenitor cells, but the
role of resident endometrial mesenchymal stem cells (eMSC) as progenitors of endometrial …