Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Since the clinical approval of imatinib, the discovery of protein kinase downregulators
entered a prosperous age. However, challenges still exist in the discovery of kinase …

Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …

The Wnt/β-catenin signaling pathway is aberrantly activated in colorectal (CRC) and many
other cancers, and novel strategies for effectively targeting it may be needed due to its …

Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

The ability for cells to harness alternative splicing enables them to diversify their proteome in
order to carry out complex biological functions and adapt to external and internal stimuli. The …

Protein kinases are well-known to orchestrate the activation of signaling cascades in
response to extracellular and intracellular stimuli to control cell proliferation and survival …

Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase
governing spindle assembly checkpoint activation and sister chromatid separation in …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …

Purpose Esophageal cancer is a common disease in China with low survival rate due to no
obvious early symptoms and lack of effective screening strategies. Traditional treatments …