Structural basis of omega-3 fatty acid transport across the blood–brain barrier
Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological
development and function, and it is supplied to the brain and eyes predominantly from …
development and function, and it is supplied to the brain and eyes predominantly from …
Recent advances in structure, function, and pharmacology of class A lipid GPCRs: opportunities and challenges for drug discovery
Great progress has been made over the past decade in understanding the structural,
functional, and pharmacological diversity of lipid GPCRs. From the first determination of the …
functional, and pharmacological diversity of lipid GPCRs. From the first determination of the …
Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent
lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that …
lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that …
SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility
W Kuang, J Zhang, Z Lan, RNVK Deepak, C Liu, Z Ma… - Cell reports, 2021 - cell.com
Ablation of Slc22a14 causes male infertility in mice, but the underlying mechanisms remain
unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner …
unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner …
Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter
E Lambert, AR Mehdipour, A Schmidt… - Nature …, 2022 - nature.com
Transport of lipids across membranes is fundamental for diverse biological pathways in
cells. Multiple ion-coupled transporters take part in lipid translocation, but their mechanisms …
cells. Multiple ion-coupled transporters take part in lipid translocation, but their mechanisms …
Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2
Prostaglandin D2 (PGD2) signals through the G protein–coupled receptor (GPCR) CRTH2
to mediate various inflammatory responses. CRTH2 is the only member of the prostanoid …
to mediate various inflammatory responses. CRTH2 is the only member of the prostanoid …
Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope
Lysophospholipid transporter LplT and acyltransferase Aas consist of a lysophospholipid-
remodeling system ubiquitously found in gram-negative microorganisms. LplT flips …
remodeling system ubiquitously found in gram-negative microorganisms. LplT flips …
Recombinant and endogenous ways to produce methylated phospholipids in Escherichia coli
J Kleetz, G Vasilopoulos, S Czolkoss, M Aktas… - Applied Microbiology …, 2021 - Springer
Escherichia coli is the daily workhorse in molecular biology research labs and an important
platform microorganism in white biotechnology. Its cytoplasmic membrane is primarily …
platform microorganism in white biotechnology. Its cytoplasmic membrane is primarily …
How to measure omega-3 fatty acid lysolipid flipping: The ultimate guide
C Perez - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Major facilitator superfamily (MFS) transporters are responsible for the translocation of a vast
amount of highly diverse substrates across biological membranes. During the last two …
amount of highly diverse substrates across biological membranes. During the last two …
Investigation of the mechanistic basis of substrate recognition and translocation by the MFS flippase LtaA
E Lambert - 2021 - edoc.unibas.ch
Lipoteichoic acids (LTA) are essential cell-wall components in Gram-positive bacteria,
including the human pathogen Staphylococcus aureus. They contribute to cell growth, cell …
including the human pathogen Staphylococcus aureus. They contribute to cell growth, cell …