The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

This article provides an overview of the patient‐specific and drug‐specific variables that can
affect drug absorption following oral product administration. The oral absorption of any …

The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding
cassette family of drug transporters and confers resistance to various anticancer drugs. We …

Over the last 50 yr, the study of intestinal peptide transport has rapidly evolved into a field
with exciting nutritional and biomedical applications. In this review, we describe from a …

Mammalian members of the SLC15 family are electrogenic transporters that utilize the
proton-motive force for uphill transport of short chain peptides and peptido-mimetics into a …

Purpose To study the correlation of intestinal absorption for drugs with various absorption
routes between human and rat, and to explore the underlying molecular mechanisms for the …

Cellular and molecular aspects of drug transport in the kidney. The kidney plays an
important role in the elimination of numerous hydrophilic xenobiotics, including drugs …

Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

Collagen is the central structural component of extracellular connective tissue, which
provides elastic qualities to tissues. For skeletal muscle, extracellular connective tissue …

The polyspecific organic cation transporters 1 and 2 (Oct1 and-2) transport a broad range of
substrates, including drugs, toxins, and endogenous compounds. Their strategic localization …