The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic
nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to …

Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

To identify regulatory drivers of prostate cancer malignancy, we have assembled genome-
wide regulatory networks (interactomes) for human and mouse prostate cancer from …

Background: The hypoxia marker pimonidazole is a candidate biomarker of cancer
aggressiveness. We investigated the transcriptional programme associated with …

Aneuploidy, an abnormal chromosome number, has been linked to aging and age-
associated diseases, but the underlying molecular mechanisms remain unknown. Here we …

Hepatocellular carcinoma (HCC) is the most common malignant liver disease in the world.
However, the mechanistic relationships among various genes and signaling pathways are …

Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant accumulation of collagen-
secreting myofibroblasts. Development of effective therapies is limited due to incomplete …

SAM-pointed domain-containing ETS transcription factor (SPDEF) is expressed in normal
prostate epithelium. While its expression changes during prostate carcinogenesis (PCa), the …

Multiple signaling pathways, structural proteins, and transcription factors are involved in the
regulation of endothelial barrier function. The forkhead protein FOXF1 is a key …

Prostate cancer is the leading cause of cancer-related mortality among men worldwide. In
particular, castration-resistant prostate cancer presents a formidable clinical challenge and …