From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association

R Ross, SN Blair, R Arena, TS Church, JP Després… - Circulation, 2016 - Am Heart Assoc
Mounting evidence has firmly established that low levels of cardiorespiratory fitness (CRF)
are associated with a high risk of cardiovascular disease, all-cause mortality, and mortality …

Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases

JC Lai, P Tandon, W Bernal, EB Tapper, U Ekong… - …, 2021 - Wiley Online Library
This is the first American Association for the Study of Liver Diseases (AASLD) practice
guidance on the management of malnutrition, frailty, and sarcopenia in patients with …

Age and liver transplantation

F Durand, J Levitsky, F Cauchy, H Gilgenkrantz… - Journal of …, 2019 - Elsevier
The average age of liver transplant donors and recipients has increased over the years.
Independent of the cause of liver disease, older candidates have more comorbidities, higher …

[HTML][HTML] Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation

DZH Levett, S Jack, M Swart, J Carlisle, J Wilson… - British journal of …, 2018 - Elsevier
The use of perioperative cardiopulmonary exercise testing (CPET) to evaluate the risk of
adverse perioperative events and inform the perioperative management of patients …

[HTML][HTML] Frailty predicts waitlist mortality in liver transplant candidates

JC Lai, S Feng, NA Terrault, B Lizaola… - American journal of …, 2014 - Elsevier
We aimed to determine whether frailty, a validated geriatric construct of increased
vulnerability to physiologic stressors, predicts mortality in liver transplant candidates …

Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: a systematic review

J Moran, F Wilson, E Guinan… - BJA: British Journal …, 2016 - academic.oup.com
Background. Cardiopulmonary exercise testing (CPET) is used as a preoperative risk-
stratification tool for patients undergoing non-cardiopulmonary intra-abdominal surgery …

Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis

L Zenith, N Meena, A Ramadi, M Yavari… - Clinical …, 2014 - Elsevier
Background & Aims Patients with cirrhosis have reduced exercise tolerance, measured
objectively as decreased peak exercise oxygen uptake (peak VO 2). Reduced peak VO 2 is …

Cardiorespiratory fitness predicts mortality and hospital length of stay after major elective surgery in older people

CP Snowden, J Prentis, B Jacques, H Anderson… - Annals of …, 2013 - journals.lww.com
Objective: This study aimed to define the relationship between cardiorespiratory fitness and
age in the context of postsurgery mortality and morbidity in older people. Background …

The liver frailty index improves mortality prediction of the subjective clinician assessment in patients with cirrhosis

JC Lai, KE Covinsky, CE McCulloch… - Official journal of the …, 2018 - journals.lww.com
OBJECTIVES: Frailty, a critical determinant of health outcomes, is most commonly assessed
in patients with cirrhosis by general clinician assessment that is limited by its subjectivity. We …