Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Regenerative capacity of adipose derived stem cells (ADSCs), comparison with mesenchymal stem cells (MSCs)

L Mazini, L Rochette, M Amine, G Malka - International journal of …, 2019 - mdpi.com
Adipose tissue is now on the top one of stem cell sources regarding its accessibility,
abundance, and less painful collection procedure when compared to other sources. The …

Concise review: mesenchymal stem cells in neurodegenerative diseases

R Volkman, D Offen - Stem cells, 2017 - academic.oup.com
Stem cell-based therapies for neurodegenerative diseases aim at halting clinical
deterioration by regeneration and by providing local support for damaged tissue …

Mammalian MSC from selected species: Features and applications

C Uder, S Brückner, S Winkler… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of
different diseases in humans and in animals. Following the guidelines of the International …

Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: a phase 1 clinical trial

HJ Kim, SW Seo, JW Chang, JI Lee… - … Research & Clinical …, 2015 - Wiley Online Library
Introduction We conducted a phase 1 clinical trial in nine patients with mild‐to‐moderate
Alzheimer's disease to evaluate the safety and dose‐limiting toxicity of stereotactic brain …

Phase I trial of repeated intrathecal autologous bone marrow-derived mesenchymal stromal cells in amyotrophic lateral sclerosis

KW Oh, C Moon, HY Kim, S Oh, J Park… - Stem cells …, 2015 - academic.oup.com
Stem cell therapy is an emerging alternative therapeutic or disease-modifying strategy for
amyotrophic lateral sclerosis (ALS). The aim of this open-label phase I clinical trial was to …

Therapeutic utility of mesenchymal stromal cell (MSC)-based approaches in chronic neurodegeneration: a glimpse into underlying mechanisms, current status, and …

M Rahbaran, AO Zekiy, M Bahramali… - Cellular & Molecular …, 2022 - Springer
Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated
therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a …

TGF-β and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer

V de Araújo Farias, AB Carrillo-Gálvez, F Martin… - Cytokine & Growth …, 2018 - Elsevier
Multipotent mesenchymal stromal cells (MSCs) represent a promising cell-based therapy in
regenerative medicine and for the treatment of inflammatory/autoimmune diseases …

Repeated intrathecal mesenchymal stem cells for amyotrophic lateral sclerosis

KW Oh, MY Noh, MS Kwon, HY Kim, S Oh… - Annals of …, 2018 - Wiley Online Library
Objective To assess the safety and efficacy of 2 repeated intrathecal injections of autologous
bone marrow–derived mesenchymal stem cells (BM‐MSCs) in amyotrophic lateral sclerosis …

Hydrogel culture surface stiffness modulates mesenchymal stromal cell secretome and alters senescence

ME Ogle, G Doron, MJ Levy… - Tissue Engineering Part …, 2020 - liebertpub.com
Current cell culture surfaces used for the expansion and production of mesenchymal stromal
cells (MSCs) are not optimized for the production of highly secretory and nonsenescent …