Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …

Bisphosphonates stop bone loss by inhibiting the activity of bone-resorbing osteoclasts.
However, the effect of bisphosphonates on bone mass cannot completely explain the …

Recent meta-analyses have revealed that the risk of bone fracture is increased in both type
1 and type 2 diabetic patients. Low bone mineral density (BMD) can not necessarily explain …

Connexin43 (Cx43) is the most abundant gap junction protein expressed in bone cells and
plays a central role in cell-to-cell communication in the skeleton. Findings of the last decade …

Osteoporosis is a major public health burden that is expected to further increase as the
global population ages. In the last twenty years, advanced glycation end products (AGEs) …

Purpose Bisphosphonates are synthetic analogues of pyrophosphate usually used in
treating bone disorders such as osteoporosis, Paget's disease, fibrous dysplasia …

Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a
critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are …

With the increasing worldwide prevalence of diabetes the resulting complications, their
consequences and treatment will lead to a greater social and financial burden on society …

Objective Advanced glycation end products (AGEs) have been implicated in the
pathogenesis of bone-destructive disorders. Yet reports on the influence of AGEs on human …

Diabetes and osteoporosis are both frequent conditions, and they may thus occur
simultaneously by chance. However, a growing body of evidence suggests that …