The key role of mitochondrial function in health and disease
I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
[HTML][HTML] Pros and cons of ultra-high-field MRI/MRS for human application
Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …
for clinical diagnostic applications and in basic research areas such as cognitive …
Insulin resistance, obesity and lipotoxicity
Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …
glucose metabolism, causes functional impairments in several metabolic pathways, both in …
Mechanisms for insulin resistance: common threads and missing links
VT Samuel, GI Shulman - Cell, 2012 - cell.com
Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
Lipid-induced insulin resistance: unravelling the mechanism
VT Samuel, KF Petersen, GI Shulman - The Lancet, 2010 - thelancet.com
Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …
The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects
LE Simental-Mendía, M Rodríguez-Morán… - … syndrome and related …, 2008 - liebertpub.com
Background: Because the insulin test is expensive and is not available in most laboratories
in the cities of undeveloped countries, we tested whether the product of fasting triglycerides …
in the cities of undeveloped countries, we tested whether the product of fasting triglycerides …
Sarcopenia: etiology, clinical consequences, intervention, and assessment
The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …
Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men
The aim of this study was to investigate the effects of very high intensity sprint interval
training (SIT) on metabolic and vascular risk factors in overweight/obese sedentary men …
training (SIT) on metabolic and vascular risk factors in overweight/obese sedentary men …
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - academic.oup.com
The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …
Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes
BH Goodpaster, J He, S Watkins… - The Journal of Clinical …, 2001 - academic.oup.com
We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is
associated with insulin resistance and that this may be mediated by the oxidative capacity of …
associated with insulin resistance and that this may be mediated by the oxidative capacity of …