The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …

Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …

Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

Background: Because the insulin test is expensive and is not available in most laboratories
in the cities of undeveloped countries, we tested whether the product of fasting triglycerides …

The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

The aim of this study was to investigate the effects of very high intensity sprint interval
training (SIT) on metabolic and vascular risk factors in overweight/obese sedentary men …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

We examined the hypothesis that an excess accumulation of intramuscular lipid (IMCL) is
associated with insulin resistance and that this may be mediated by the oxidative capacity of …