Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …

How individual genes are regulated from a mitochondrial polycistronic transcript to have
variable expression remains an enigma. Here, through bisulfite sequencing and strand …

TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene
expression. Dysregulation of their activity is associated with many serious pathogenic states …

One-carbon metabolism provides the methyl groups for both DNA and histone tail
methylation reactions, two of the main epigenetic processes that tightly regulate the …

Epigenetics provides an important layer of information on top of the DNA sequence and is
essential for establishing gene expression profiles. Extensive studies have shown that …

Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the
origin of two of these stresses, namely mitochondrial metabolic compromise, associated with …