Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
Mitochondrial DNA in innate immune responses and inflammatory pathology
Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …
[HTML][HTML] Mitochondrial DNA methylation and human diseases
A Stoccoro, F Coppedè - International Journal of Molecular Sciences, 2021 - mdpi.com
Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …
Mitochondrial function in development and disease
MP Rossmann, SM Dubois… - Disease models & …, 2021 - journals.biologists.com
Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …
[HTML][HTML] Evidence suggesting absence of mitochondrial DNA methylation
M Mechta, LR Ingerslev, O Fabre, M Picard… - Frontiers in …, 2017 - frontiersin.org
Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …
The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A
X Dou, JD Boyd-Kirkup, J McDermott, X Zhang… - Genome …, 2019 - genome.cshlp.org
How individual genes are regulated from a mitochondrial polycistronic transcript to have
variable expression remains an enigma. Here, through bisulfite sequencing and strand …
variable expression remains an enigma. Here, through bisulfite sequencing and strand …
[HTML][HTML] TET protein inhibitors: Potential and limitations
R Kaplánek, Z Kejík, J Hajduch, K Veselá… - Biomedicine & …, 2023 - Elsevier
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene
expression. Dysregulation of their activity is associated with many serious pathogenic states …
expression. Dysregulation of their activity is associated with many serious pathogenic states …
One-carbon epigenetics and redox biology of neurodegeneration
F Coppedè - Free Radical Biology and Medicine, 2021 - Elsevier
One-carbon metabolism provides the methyl groups for both DNA and histone tail
methylation reactions, two of the main epigenetic processes that tightly regulate the …
methylation reactions, two of the main epigenetic processes that tightly regulate the …
[PDF][PDF] Regulation of mitochondrial gene expression, the epigenetic enigma
A Mposhi, MG Van der Wijst, KN Faber… - Front Biosci (Landmark …, 2017 - core.ac.uk
Epigenetics provides an important layer of information on top of the DNA sequence and is
essential for establishing gene expression profiles. Extensive studies have shown that …
essential for establishing gene expression profiles. Extensive studies have shown that …
[HTML][HTML] Replication stress at telomeric and mitochondrial DNA: common origins and consequences on ageing
P Billard, DA Poncet - International Journal of Molecular Sciences, 2019 - mdpi.com
Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the
origin of two of these stresses, namely mitochondrial metabolic compromise, associated with …
origin of two of these stresses, namely mitochondrial metabolic compromise, associated with …