Furin is the first discovered proprotein convertase member and is present in almost all
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …

Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides
and peptide hormones that perform multiple functions, including regulation of body weight …

Background Vascular fibrosis directly causes vascular thickening in Takayasu arteritis (TAK),
in which sustained transforming growth factor beta (TGF-β) activation is critical …

Autosomal dominant polycystic kidney disease, autosomal recessive polycystic kidney
disease, and nephronophthisis are hereditary disorders with the occurrence of numerous …

Abstract Proprotein Convertases (PCs) are serine endoproteases that regulate the
homeostasis of protein substrates in the cell. The PCs family counts 9 members—PC1/3 …

Cilia are sensory and secretory organelles that both receive information from the
environment and transmit signals. Cilia-derived vesicles (ectosomes), formed by outward …

Proprotein convertase (PCSK) enzymes serve a wide range of regulatory roles in mammals,
for example in metabolism and immunity, and altered activity of PCSKs is associated with …

Abstract Epithelial Na+ channels (ENaCs) are activated by proteolysis of the α and γ
subunits at specific sites flanking embedded inhibitory tracts. To examine the role of α …

Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in
most major organs, where it cleaves a wide range of growth factors, signaling molecules …

Background A hitherto undescribed form of diabetes mellitus type 2 is reported in a Flemish
family. In these patients, markedly elevated gastrin levels were observed, which could not be …