Interleukins (ILs) are a major subclass of cytokines acting as molecular messengers playing
role in immune system responses via a cascade of signaling pathways. Belonging to the …

The concept of hematopoietic stem cell (HSC) niche was formulated in 1978, but HSC
niches remained unidentified for the following two decades largely owing to technical …

The major dose-limiting toxicity of interleukin-2 (IL-2) and of immunotoxin (IT) therapies is
vascular leak syndrome (VLS). VLS is characterized by an increase in vascular permeability …

Myeloid growth factors (MGFs) are given as supportive care to patients receiving
myelosuppressive chemotherapy to reduce the incidence of neutropenia. This selection from …

Thrombocytopenia is a common complication in liver disease and can adversely affect the
treatment of liver cirrhosis, limiting the ability to administer therapy and delaying planned …

Chemotherapeutic agents are used extensively in solid and hematologic malignancies and
are increasingly used for their immunosuppressive properties in the management of …

Over the last twenty years research has provided an important insight into the mechanisms
responsible for the immunotoxicity of both local and systemic adverse reactions following the …

Cytokines have a major role in promoting the growth and spread of cancers. Elevated levels
of several cytokines have been described in cancer patients. Evidence from animal and …

Cancer pain is prevalent and heterogeneous, 1 and effective treatment begins with
assessment (see Regina M. Fink and Jeannine M. Brants' article,“Complex Cancer Pain …

В монографии представлены сведения о фармакологической активности и механизмах
действия препаратов на основе сверхмалых доз антител к эндогенным регуляторам …