Repurposing of kinase inhibitors for treatment of COVID-19
The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …
Oncolytic virotherapy
SJ Russell, KW Peng, JC Bell - Nature biotechnology, 2012 - nature.com
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection
J Dyall, CM Coleman, T Venkataraman… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Outbreaks of emerging infections present health professionals with the unique challenge of
trying to select appropriate pharmacologic treatments in the clinic with little time available for …
trying to select appropriate pharmacologic treatments in the clinic with little time available for …
Middle East respiratory syndrome and severe acute respiratory syndrome: current therapeutic options and potential targets for novel therapies
J Dyall, R Gross, J Kindrachuk, RF Johnson… - Drugs, 2017 - Springer
No specific antivirals are currently available for two emerging infectious diseases, Middle
East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A …
East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A …
Identification of SARS-CoV-2 entry inhibitors among already approved drugs
L Yang, R Pei, H Li, X Ma, Y Zhou, F Zhu… - Acta Pharmacologica …, 2021 - nature.com
To discover effective drugs for COVID-19 treatment amongst already clinically approved
drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry …
drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry …
Subversion of the actin cytoskeleton during viral infection
Viral infection converts the normal functions of a cell to optimize viral replication and virion
production. One striking observation of this conversion is the reconfiguration and …
production. One striking observation of this conversion is the reconfiguration and …
[HTML][HTML] A comprehensive review on the global efforts on vaccines and repurposed drugs for combating COVID-19
The recently discovered coronavirus, known as SARS-CoV-2, is a highly contagious and
potentially lethal viral infection that was declared a pandemic by the World Health …
potentially lethal viral infection that was declared a pandemic by the World Health …
Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies
Monkeypox is a rare zoonotic disease caused by infection with the monkeypox virus. The
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …
disease can result in flu‐like symptoms, fever, and a persistent rash. The disease is currently …
An overview of antivirals against monkeypox virus and other orthopoxviruses
J Wang, M Shahed-AI-Mahmud, A Chen… - Journal of medicinal …, 2023 - ACS Publications
The current monkeypox outbreaks during the COVID-19 pandemic have reignited interest in
orthopoxvirus antivirals. Monkeypox belongs to the Orthopoxvirus genus of the Poxviridae …
orthopoxvirus antivirals. Monkeypox belongs to the Orthopoxvirus genus of the Poxviridae …
Preparing for the next viral threat with broad-spectrum antivirals
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …
hundreds of viruses known to cause human disease and for the establishment of a …