Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of
essential processes in humans from embryonic development to adult tissue homeostasis …

The human genetic factors that affect resistance to infectious disease are poorly understood.
Here we report a genome-wide association study in 17,000 severe malaria cases and …

In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …

Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the
life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life …

Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The
molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is …

Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases
caused by viruses and intracellular bacteria, but its implementation in the context of parasitic …

Macropinocytosis has long been known as a primary method for cellular intake of fluid-
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies …

Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect
the liver for an initial round of replication before the emergence of pathogenic blood stages …

The EphA2 receptor tyrosine kinase plays key roles in tissue homeostasis and disease
processes such as cancer, pathological angiogenesis, and inflammation through two distinct …