Harmonizing the neurobiology and treatment of obsessive-compulsive disorder
WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …
disorder. The only established first-line treatments for OCD are exposure and response …
The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms
EJ Nestler, C Lüscher - Neuron, 2019 - cell.com
Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …
develops compulsive use that does not stop even in light of major negative consequences …
The effect of machine learning regression algorithms and sample size on individualized behavioral prediction with functional connectivity features
Individualized behavioral/cognitive prediction using machine learning (ML) regression
approaches is becoming increasingly applied. The specific ML regression algorithm and …
approaches is becoming increasingly applied. The specific ML regression algorithm and …
Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …
human behaviors such as evaluation, affect regulation and reward-based decision-making …
[HTML][HTML] Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in obsessive-compulsive disorder: evidence from resting-state …
Background A recent hypothesis has suggested that core deficits in goal-directed behavior
in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We …
in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We …
Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional …
Neuroimaging studies report evidence for two distinct pathophysiological models of
obsessive-compulsive disorder (OCD): disrupted fronto-striatal circuits and impaired large …
obsessive-compulsive disorder (OCD): disrupted fronto-striatal circuits and impaired large …
Striatal circuits, habits, and implications for obsessive–compulsive disorder
Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …
support.•This evidence is concordant with clinical evidence based on OCD patient …
Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis
J Liu, L Cao, H Li, Y Gao, X Bu, K Liang, W Bao… - Neuroscience & …, 2022 - Elsevier
Obsessive-compulsive disorder (OCD) displays widespread disruption across brain regions
revealed by resting-state functional connectivity (rsFC) with inconsistent results between …
revealed by resting-state functional connectivity (rsFC) with inconsistent results between …
The role of self-compassion in buffering symptoms of depression in the general population
Self-compassion, typically operationalized as the total score of the Self-Compassion Scale
(SCS; Neff, 2003b), has been shown to be related to increased psychological well-being …
(SCS; Neff, 2003b), has been shown to be related to increased psychological well-being …
Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder
Background Obsessive-compulsive disorder (OCD) is associated with regional hyperactivity
in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity …
in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity …