DNA repair in neurons: so if they don't divide what's to repair?
ML Fishel, MR Vasko, MR Kelley - Mutation Research/Fundamental and …, 2007 - Elsevier
Neuronal DNA repair remains one of the most exciting areas for investigation, particularly as
a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …
a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …
The impact of base excision DNA repair in age-related neurodegenerative diseases
GS Leandro, P Sykora, VA Bohr - Mutation Research/Fundamental and …, 2015 - Elsevier
The aging process and several age-related neurodegenerative disorders have been linked
to elevated levels of DNA damage induced by ROS and deficiency in DNA repair …
to elevated levels of DNA damage induced by ROS and deficiency in DNA repair …
[PDF][PDF] RETRACTED: Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner
J Moser, H Kool, I Giakzidis, K Caldecott… - Molecular cell, 2007 - cell.com
Impaired gap filling and sealing of chromosomal DNA in nucleotide excision repair (NER)
leads to genome instability. XRCC1-DNA ligase IIIα (XRCC1-Lig3) plays a central role in the …
leads to genome instability. XRCC1-DNA ligase IIIα (XRCC1-Lig3) plays a central role in the …
DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability
DJ Bentley, J Selfridge, JK Millar, K Samuel, N Hole… - Nature …, 1996 - nature.com
Four distinct DMA ligase activities (I-IV) have been identified within mammalian cells1–3.
Evidence has indicated that DNA ligase I is central to DMA replication4–7, as well as being …
Evidence has indicated that DNA ligase I is central to DMA replication4–7, as well as being …
Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents
S Gupta, P Maurya, A Upadhyay, P Kushwaha… - European journal of …, 2018 - Elsevier
DNA replication and repair are complex processes accomplished by the concerted action of
a network of enzymes and proteins. DNA ligases play a crucial role in these processes by …
a network of enzymes and proteins. DNA ligases play a crucial role in these processes by …
DNA ligase I and proliferating cell nuclear antigen form a functional complex
S Tom, LA Henricksen, MS Park… - Journal of Biological …, 2001 - ASBMB
DNA ligase I is responsible for joining Okazaki fragments during DNA replication. An
additional proposed role for DNA ligase I is sealing nicks generated during excision repair …
additional proposed role for DNA ligase I is sealing nicks generated during excision repair …
Altered DNA ligase activity in human disease
AE Tomkinson, T Naila, S Khattri Bhandari - Mutagenesis, 2020 - academic.oup.com
The joining of interruptions in the phosphodiester backbone of DNA is critical to maintain
genome stability. These breaks, which are generated as part of normal DNA transactions …
genome stability. These breaks, which are generated as part of normal DNA transactions …
The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer
E Martínez-Terroba, T Ezponda, C Bértolo… - Laboratory …, 2018 - nature.com
In recent years, the relevance of RNA metabolism has been increasingly recognized in a
variety of diseases. Modifications in the levels of RNA-binding proteins elicit changes in the …
variety of diseases. Modifications in the levels of RNA-binding proteins elicit changes in the …
Base excision repair in the mammalian brain: implication for age related neurodegeneration
P Sykora, DM Wilson III, VA Bohr - Mechanisms of ageing and …, 2013 - Elsevier
The repair of damaged DNA is essential to maintain longevity of an organism. The brain is a
matrix of different neural cell types including proliferative astrocytes and post-mitotic …
matrix of different neural cell types including proliferative astrocytes and post-mitotic …