Stroke is a serious neurological disease, and constitutes a major cause of death and
disability throughout the world. The pathophysiology of stroke is complex, and involves …

Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

The endothelium, once considered a mere selectively permeable barrier between the
bloodstream and the outer vascular wall, is now recognized to be a crucial homeostatic …

Background and Purpose—To design appropriate molecular genetic studies, we first need
to understand the genetic epidemiology of stroke. We therefore performed a systematic …

Ischaemic stroke is a heterogeneous multifactorial disorder. Epidemiological data provide
substantial evidence for a genetic component to the disease, but the extent of predisposition …

We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped
this locus and tested it for association with stroke. We found the strongest association in the …

Background and Purpose—About 60% to 80% of all ischemic strokes can be attributed to
increasing blood pressure, blood cholesterol, cigarette smoking, carotid stenosis, and …

Objective To find sequence variants that associate with the risk for ischemic stroke (IS), we
performed a genome‐wide association study. Methods We genotyped 1,661 Icelandic IS …

Understanding the genetic risk factors for stroke is an essential step to decipher the
underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize …

Background and Purpose—Twin and family history studies support a role for genetic factors
in stroke risk. Because the etiology of ischemic stroke is heterogeneous, genetic factors may …