Extracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of
proteins and RNAs for intercellular communication. With various biomolecules and specific …

Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins
characterized by four transmembrane domains. They participate in a variety of cellular …

Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat,
owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences …

Tetraspanins comprise a diverse family of four-pass transmembrane proteins that play
critical roles in the immune, reproductive, genitourinary, and auditory systems. Despite their …

An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
Many studies show that the expression of tetraspanins correlates with tumour stage, tumour …

Tumours progress through a cascade of events that enable the formation of metastases.
Some of the components that are required for this fatal process are well established …

Mutations in the genes encoding the Wnt receptor Frizzled-4 (FZD4), coreceptor LRP5, or
the ligand Norrin disrupt retinal vascular development and cause ophthalmic diseases …

The tetraspanin transmembrane proteins have emerged as key players in malignancy, the
immune system, during fertilization and infectious disease processes. Tetraspanins engage …

Fertilization is a multistep process that culminates in the fusion of sperm and egg, thus
marking the beginning of a new organism in sexually reproducing species. Despite its …

Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal
vascular system. Although mutations in three genes (LRP5, FZD4, and NDP) are known to …