Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

The anti-tumor effects of chemotherapy and radiation are thought to be mediated by
triggering G1/S or G2/M cell cycle checkpoints, while spindle poisons, such as paclitaxel …

We have developed a mathematical model of the mouse ventricular myocyte action potential
(AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever …

The force–frequency relationship (FFR) is an important intrinsic regulatory mechanism of
cardiac contractility. The FFR in most mammalian ventricular myocardium is positive; that is …

To date, numerous biosensing platforms have been developed for assessing drug-induced
cardiac toxicity by measuring the change in contractile force of cardiomyocytes. However …

In ventricular cardiac myocytes, T-tubule density is an important determinant of the
synchrony of sarcoplasmic reticulum (SR) Ca2+ release and could be involved in the …

Rationale: Persistent atrial fibrillation (AF) has been associated with structural and electric
remodeling and reduced contractile function. Objective: To unravel mechanisms underlying …